Complex signatures of natural selection at GYPA
نویسندگان
چکیده
منابع مشابه
Molecular signatures of natural selection.
There is an increasing interest in detecting genes, or genomic regions, that have been targeted by natural selection. The interest stems from a basic desire to learn more about evolutionary processes in humans and other organisms, and from the realization that inferences regarding selection may provide important functional information. This review provides a nonmathematical description of the i...
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Many lines of evidence show that several HLA loci have experienced balancing selection. However, distinguishing among demographic and selective explanations for patterns of variation observed with HLA genes remains a challenge. In this study we address this issue using data from a diverse set of human populations at six classical HLA loci and, employing a comparative genomics approach, contrast...
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ژورنال
عنوان ژورنال: Human Genetics
سال: 2018
ISSN: 0340-6717,1432-1203
DOI: 10.1007/s00439-018-1866-3